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Hepatocyte Growth Factor as an Indicator of Reduced Handgrip Strength among Non-Overweight Hypertensive Elderly Men

Background: Age-related loss of skeletal muscle mass and function is reported to be associated with impairment of capillary functions. Hepatocyte growth factor (HGF) has been evaluated as a possible biochemical index of hypertension-induced vascular damage which also impairs capillary functions.
Aims: The present study aimed to clarify the clinical importance of HGF on handgrip strength (marker of loss of skeletal muscle mass and function) in hypertensive elderly men.
Methods: We conducted a cross-sectional study of 191 hypertensive elderly men (60-69 years). Since low body mass index (BMI) is one of the well-known risk factors for age-related loss of skeletal muscle mass and function, nonoverweight (BMI<25 kg/m2) subjects are a high risk group for this phenomenon. To investigate the association between HGF and handgrip strength BMI status also should be accounting.
Results: From multivariable linear regression analysis adjusted for known cardiovascular risk factors, we found a significant inverse association between handgrip strength and the logarithm of serum HGF concentration for nonoverweight elderly men but not for overweight elderly men; Β (parameter estimate)=-2.34, β (standardized parameter estimate)=-0.21, p=0.020 for non-overweight and Β=0.87, β=0.07, p=0.585 for overweight, respectively. Conclusion: We found a significant inverse association between handgrip strength and HGF in non-overweight hypertensive men. This result indicates that HGF and status of BMI may be a useful indicator to evaluate hypertension related loss of skeletal muscle mass and function.


Yuji Shimizu, Mio Nakazato, Shimpei Sato, Mako Nagayoshi, Koichiro Kadota, Yuko Noguchi, Jun Koyamatsu, Hirotomo Yamanashi, Kazuhiko Arima and Takahiro Maeda

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