Journal of Allergy & Inflammation

About Journal of Allergy & Inflammation

Inflammation is the body's response to tissue damage. Unless death occurs, inflammation is always followed by repair, while allergy is an exaggerated immune response to contact with a foreign substance, which may be something ingested, inhaled or touched. The immune response causes tissue swelling as seen in something as innocuous as hives or something as fatal as narrowing of the respiratory passages by surrounding bloated tissue. The ever growing pollution has caused allergic responses a regular issue especially in the urban life of human being. The Journal of Allergy and Inflammation presents a spectrum of exciting information on various approaches adopted and their possible outcomes in allergy and inflammation research including new strategies in diagnosis, therapy and prevention of allergic diseases and inflammation. We will facilitate article submission, rapid article quality assurance through 'peer review', article formatting and processing to a final product which will allow high visibility, impact and provoke debate.

Submit manuscript at http://www.editorialmanager.com/imedpub/ or send as an e-mail attachment to the Editorial Office at [email protected] 

Acute Inflammation

Acute inflammation is the early (almost immediate) response of a tissue to injury. It is nonspecific and may be evoked by any injury short of one that is immediately lethal. Acute inflammation may be regarded as the first line of defense against injury and is characterized by changes in the microcirculation exudation of fluid and emigration of leukocytes from blood vessels to the area of injury. Acute inflammation is typically of short duration, occurring before the immune response becomes established, and it is aimed primarily at removing the injurious agent.

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Allergen

An allergen is a substance that can cause an allergic reaction. In some people, the immune system recognizes allergens as foreign or dangerous. As a result, the immune system reacts by making a type of antibody called IgE to defend against the allergen. This reaction leads to allergy symptoms.

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Allergic conjunctivitis

Allergic conjunctivitis is an inflammatory response of the conjunctiva to an allergen. It is part of a larger systemic atopic reaction and is usually seasonal with associated upper respiratory tract symptoms and complaints of redness and swelling of the conjunctiva with severe itching and increased lacrimation. Presence of rhinitis often terms this process as allergic rhinoconjunctivitis.

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Allergic Inflammation

Allergic inflammation is due to a complex interaction between several inflammatory cells, including mast cells, basophils, lymphocytes, dendritic cells, eosinophil, and sometimes neutrophils. These cells produce multiple inflammatory mediators, including lipids, purines, cytokines, chemokine, and reactive oxygen species.

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Allergic rhinitis

Allergic rhinitis develops when the body’s immune system becomes sensitized and overreacts to something in the environment that typically causes no problem in most people. It is defined as symptoms of sneezing, nasal pruritus, airflow obstruction, and mostly clear nasal discharge caused by IgE-mediated reactions against inhaled allergens and involving mucosal inflammation driven by type 2 helper T (Th2) cells.

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Allergy

Allergy is an exaggerated immune response to contact with a foreign substance, which may be something ingested (peanut allergy), inhaled (pollen and dander) or touched. The immune response causes tissue swelling as seen in something as innocuous as hives or something as fatal as narrowing of the respiratory passages by surrounding bloated tissue.

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Anaphylaxis

Anaphylaxis is an extreme and severe allergic reaction. The whole body is affected, often within minutes of exposure to the substance which causes the allergic reaction (allergen) but sometimes after hours. The symptoms are caused by the sudden release of chemical substances, including histamine, from cells in the blood and tissues where they are stored. The release is triggered by the interaction between an allergic antibody called Immunoglobulin E (IgE) and the substance (allergen) causing the anaphylactic reaction.

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Angioedema

Angioedema is edema of the deep dermis and subcutaneous tissues. It is usually an acute mast cell–mediated reaction caused by exposure to drug, venom, dietary, pollen, or animal dander allergens. Angioedema can also be an acute reaction to ACE inhibitors, a chronic reaction, or a hereditary or an acquired disorder characterized by an abnormal complement response.

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Appendicitis

Appendicitis is a painful medical condition in which the appendix becomes inflamed and filled with pus, a fluid made up of dead cells and inflammatory tissue that often results from an infection. This can lead to peritonitis, a serious inflammation of the abdominal cavity's lining (the peritoneum) that can be fatal unless it is treated quickly with strong antibiotics. Inflammation of this abdominal organ can be a serious and life-threatening condition.

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Asthma

Inflammatory disease caused to the lungs. It causes breathlessness. It is a chronic disease. Timing of symptoms is based on the physical activity. It is caused by the combination of genetic and environmental factors.

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Bronchitis

Bronchitis is an inflammation of the bronchial tubes, the airways that carry air to your lungs. Individuals with bronchitis have a reduced ability to breathe air and oxygen into their lungs. It causes shortness of breath, wheezing, a low fever, and chest tightness. Often developing from a cold or other respiratory infection, acute bronchitis is very common. Chronic bronchitis, a more serious condition, is a constant irritation or inflammation of the lining of the bronchial tubes, often due to smoking.

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Crohn’s Disease

Crohn's disease is a chronic condition that causes inflammation of the digestive tract. It is a type of inflammatory bowel disease (IBM) that can be painful, debilitating, and, sometimes, life-threatening. It is also termed as ileitis or enteritis that can affect any part of the gut, from the mouth all the way down to the anus but more commonly found at the end of the small intestine.

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Cystitis

Cystitis is the medical term for inflammation of the bladder that affects up to 40% of women. Most of the time, the inflammation is caused by a bacterial infection, and it's called a urinary tract infection (UTI). The bladder is a muscular bag that stores urine from the kidneys. Urine leaves the body through a tube called the urethra. Cystitis occurs when bacteria travel up the urethra, infect the urine and inflame the bladder lining.

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Dermatitis

Dermatitis is a non-contagious skin inflammation, but it embraces a range of ailments. The early stages of dermatitis are characterized by red, dry, and itchy skin. However, more serious dermatitis may result in crusty scales, painful cracks, or blisters that ooze fluid. Atopic dermatitis is inherited and usually occurs first when children are infants. Contact dermatitis occurs when the skin comes in contact with something that causes an allergic reaction (allergic contact dermatitis) and injures the skin.

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Eczema

Eczema is a condition where patches of skin become inflamed, itchy, red, cracked, and rough. Blisters may sometimes occur. It is non-contagious, more likely caused by both genetic and environmental factors. There are about 11 distinct types of skin conditions that produce eczema namely Atopic, Irritant, Allergic contact, Stasis dermatitis, Fungal infection, Scabies, Pompholyx, Lichen simplex chronicus, Nummular eczema, Xerotic eczema and Seborrheic dermatitis.

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Histamine Intolerence

Histamine intolerance occurs when there is a buildup of histamine in the body. Drugs, medical conditions, the environment, nutritional deficiencies, and diet can lead to histamine intolerance. Symptoms of histamine intolerance include migraines, nasal congestion, fatigue, digestive issues, irregular menstrual cycle, nausea, abdominal cramping, anxiety and dizziness.

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Inflammation

Inflammation is a defense mechanism in the body. It is a process by which the body's white blood cells and substances they produce protect us from infection with foreign organisms, such as bacteria and viruses. The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair.

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Nephritis

Nephritis, also termed as glomerulonephritis, is a group of diseases that cause inflammation of the nephrons which can reduce the filtration capability of kidneys. Most types of nephritis are caused by the body’s immune system that makes antibodies to attack bacteria or poisons. These antibodies can damage the kidneys and nephrons, causing swelling and scarring.

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Oral allergy syndrome

Oral Allergy Syndrome (OAS), also known as pollen-food syndrome, is caused by cross-reacting allergens found in both pollen and raw fruits, vegetables, or some tree nuts. The immune system recognizes the pollen and similar proteins in the food and directs an allergic response to it. OAS is a form of a contact allergic reaction that occurs upon contact of the mouth and throat with raw fruits or vegetables. The most frequent symptoms of OAS include itchiness or swelling of the mouth, face, lip, tongue and throat.

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Otitis media

Otitis media (OM) is any inflammation of the middle ear characterized by the accumulation of infected fluid in the middle ear, bulging of the eardrum, pain in the ear and, if eardrum is perforated, drainage of purulent material (pus) into the ear canal. Upper respiratory infections are a prominent risk factor for acute otitis media so exposure to groups of children as in child-care centers results in more frequent colds and therefore more ear infections.

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Pelvic Inflammatory Disease

Pelvic inflammatory disease (PID) is an infection of the upper part of the female reproductive system namely the uterus, fallopian tubes, and ovaries, and inside of the pelvis. Pelvic inflammatory disease many not produce any symptoms or signs (referred to as being asymptomatic). In other cases it can cause fever, abdominal or pelvic pain, vaginal discharge, painful urination or painful sexual intercourse.

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Psoriasis

Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. It varies in severity from small, localized patches to complete body coverage. Psoriasis is a common skin condition that speeds up the life cycle of skin cells. It causes cells to build up rapidly on the surface of the skin. The extra skin cells form scales and red patches that are itchy and sometimes painful.

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Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease in which the body’s immune system, which normally protects its health by attacking foreign substances like bacteria and viruses –mistakenly attacks the joints. This creates inflammation which causes the tissue that lines the inside of joints (the synovium) to thicken, resulting in swelling and pain in and around the joints. The synovium makes a fluid that lubricates joints and helps them move smoothly.

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Suppurative Inflammation

It is also called as lymphocytic inflammation. Suppurative is a term used to describe a disease or condition in which a purulent exudate (pus) is formed and discharged. Examples of such condition include appendicitis, arthritis, cerebritis, choroiditis, encephalitis, endophthalmitis, gastritis, gingivitis, hepatitis, hyalitis, mastitis, nephritis, pancreatitis, periodontitis, and phlebitis. Inflammation accompanied by pus formation is referred to as suppurative inflammation. In contrast, an inflammation not accompanied or characterized by suppuration is called nonsuppurative inflammation.

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Tonsilitis

Tonsillitis is an inflammation of the tonsils, two lymph nodes located on each side at the back of the throat. They generally function as a defense mechanism, helping to prevent the body from infection. Most cases of tonsillitis are caused by infection with a common virus, but bacterial infections also may cause tonsillitis. Signs and symptoms of tonsillitis include swollen tonsils, sore throat, difficulty swallowing and tender lymph nodes on the sides of the neck.

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Vaginitis

Vaginitis is an inflammation of the vagina that often occurs in combination with inflammation of the vulva, a condition known as vulvovaginitis. It is often the result of an infection with yeast, bacteria, or Trichomonas, but it may also arise due to physical or chemical irritation of the area. Vaginitis is not always caused by a sexually transmitted infection. It may cause by an upset in the balance of bacteria that is normal in the vagina.

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Vasculitis

Vasculitis is a term for a group of rare diseases that have in common inflammation of blood vessels. These vessels include arteries and veins. When blood vessels become inflamed, they may become weakened, stretch, and either increase in size or become narrow, even to the point of closing entirely. It is primarily caused by leukocyte migration and resultant damage. Vasculitis has a wide range of signs and symptoms such as shortness of breath and cough, numbness or weakness in a hand or foot, purpura, nodules and ulcers.

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